The person’s Red Blood Cells may have a form or structure that is not common or usual. R-null cells lack Rh polypeptides and are deficient in Rh-associated glycoprotein and glycophorin. The Rh-null blood type predominantly arises due to lack of Rh blood group antigens, or when the Rh antigens decrease severely.īlood from these patients does not react with antiseras. Lack of or severe reduction of Rh blood group antigens These patients experience chronic haemolysis, with varying severity and characterized by stomatocytosis, spherocytosis, defective cation fluxes and other conditions. The defect in the RHAG gene leads to the Rh-null condition. There is also a regulator’ type of the Rh- null phenomenon. There is an amorph type of the condition, which is brought about by at least two different genetic mechanisms, particularly a molecular change in the RHCE gene, with a deleted RHD gene. Molecular Change in RHCE gene, with a deleted RHD gene These patients exhibit subsequent chronic haemolytic anaemia, whose degree varies from patient to patient. People with this syndrome are known to have osmotically fragile Red Blood Cells, called stomatocytes. Patients who suffer from the Rh-null phenomenon are said to suffer from the Rh-null syndrome. The genetic composition of blood cells could change over time, giving rise to Rh- blood. The Rh-null blood type can also be brought about by genetic mutations. It develops when individuals inherit a suppressor gene unrelated to the RH locus or a silent allele at the locus itself. This makes it almost impossible for other people to develop it without a family history of the blood type. The Rh-null blood type is inherited and has been known to run in families.Ĭhildren inherit the rare condition from their parents or other people in their lineage. This may be due to environmental conditions of the region.įor example, if you perform a research on identifying what blood type is rare in East Asia, you may find it to be d ifferent from one place to another. Several among rare blood types are more prevalent in specific parts of the world where they manifest.ĭuffy-negative blood is unique to people of African origin while Rh-null blood occurs more in people living around East Asia.
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